Alteration of central motor excitability in a patient with hemimasticatory spasm after treatment with botulinum toxin injections
- 17 August 2005
- journal article
- case report
- Published by Wiley in Movement Disorders
- Vol. 21 (1), 73-78
- https://doi.org/10.1002/mds.20653
Abstract
Hemimasticatory spasm (HMS) is a condition characterized by paroxysmal involuntary contraction of masticatory muscles. We performed an electrophysiological investigation of a single patient with HMS to identify any pathophysiological changes associated with the condition. We identified a delayed M wave and jaw jerk on the affected side and an absent masseteric silent period during spasm. Botulinum toxin injections successfully treated the clinical symptoms and resulted in a significant reduction in the excitability of the blink reflex recovery cycle. These data suggest that HMS may be due to ectopic activity in the motor portion of the trigeminal nerve that is capable of inducing changes in the excitability of central reflex pathways. These changes can be altered by successful treatment with botulinum toxin. © 2005 Movement Disorder SocietyKeywords
This publication has 24 references indexed in Scilit:
- Brainstem reflexes: Electrodiagnostic techniques, physiology, normative data, and clinical applicationsMuscle & Nerve, 2002
- Hemimasticatory spasm in hemifacial atrophy: Diagnostic and therapeutic aspects in two patientsMovement Disorders, 1995
- Pathophysiology of hemimasticatory spasm.Journal of Neurology, Neurosurgery & Psychiatry, 1994
- Modulation of the Electrically Evoked Blink Reflex by Different Levels of Tonic Preinnervation of the Orbicularis Oculi MuscleInternational Journal of Neuroscience, 1994
- Neurophysiological observations on the effects of botulinum toxin treatment in patients with dystonic blepharospasm.Journal of Neurology, Neurosurgery & Psychiatry, 1991
- FUNCTIONAL ORGANIZATION OF THE TRIGEMINAL MOTOR SYSTEM IN MANBrain, 1989
- Focal dystonia of the jaw and the differential diagnosis of unilateral jaw and masticatory spasm.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- Hemimasticatory spasm --a peripheral paroxysmal cranial neuropathy?Journal of Neurology, Neurosurgery & Psychiatry, 1983
- Masticatory spasm in facial hemiatrophyAnnals of Neurology, 1980
- On the Question of Permeability of the Blood-Brain Barrier to Botulinum ToxinInternational Archives of Allergy and Immunology, 1975