Combined Intra-arterial and Systemic Chemotherapy for Recurrent Malignant Brain Tumors
- 1 February 1992
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurosurgery
- Vol. 30 (2), 223-227
- https://doi.org/10.1227/00006123-199202000-00012
Abstract
Seventy-nine patients harboring recurrent brain tumors received four cycles of infraophthalmic carotid injections of 160 mg of carmustine. Two milligrams of intravenous vincristine and 50 mg of oral procarbazine was also administered three times daily for 1 week in conjunction with each BCNU treatment. The response rate was 60% with a median survival for patients with astrocytomas, anaplastic astrocytomas, and glioblastomas of 32, 20, and 6.5 months, respectively. The median survival of the responding patients was 20 months, and the survival at 30 months was 45%. The survival in patients not responding to treatment was 5 months, reflecting the natural history of the tumor. There have been no deaths related to the treatment procedure. No incidents of severe or permanent eye complications or leukoencephalopathy were observed. Based on multivariate survival analysis, only patients with a good performance status who are not steroid dependent are candidates for this treatment.Keywords
This publication has 14 references indexed in Scilit:
- Treatment of malignant recurrent glioma by infra-arterial, infra-ophtalmic infusion of HECNU 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl) ureaJournal of Neuro-Oncology, 1990
- Low-grade astrocytomas: Treatment results and prognostic variablesInternational Journal of Radiation Oncology*Biology*Physics, 1988
- Reoperation in the Treatment of Recurrent Intracranial Malignant GliomasNeurosurgery, 1987
- Misonidazole and CCNU chemotherapy for recurrent primary brain tumorJournal of Neuro-Oncology, 1987
- Intra-arterial BCNU chemotherapy for treatment of malignant gliomas of the central nervous systemJournal of Neurosurgery, 1984
- Chemosensitivity of malignant human brain tumorsJournal of Neuro-Oncology, 1983
- Quality and Duration of Survival in Glioblastoma MultiformePublished by American Medical Association (AMA) ,1979
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examplesBritish Journal of Cancer, 1977
- Treatment of Malignant GliomaArchives of Neurology, 1976
- Maximum utilization of the life table method in analyzing survivalJournal of Chronic Diseases, 1958