IgA Function in Relation to the Intestinal Microbiota
- 26 April 2018
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 36 (1), 359-381
- https://doi.org/10.1146/annurev-immunol-042617-053238
Abstract
IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of microbiota colonization following colonization in germ-free animals, until recently appreciation of the function of IgA in host-microbial mutualism has depended mainly on indirect evidence of alterations in microbiota composition or penetration of microbes in the absence of somatic mutations in IgA (or compensatory IgM). Highly parallel sequencing techniques that enable high-resolution analysis of either microbial consortia or IgA sequence diversity are now giving us new perspectives on selective targeting of microbial taxa and the trajectory of IgA diversification according to induction mechanisms, between different individuals and over time. The prospects are to link the range of diversified IgA clonotypes to specific antigenic functions in modulating the microbiota composition, position and metabolism to ensure host mutualism. Expected final online publication date for the Annual Review of Immunology Volume 36 is April 26, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Keywords
This publication has 113 references indexed in Scilit:
- Statistical inference of the generation probability of T-cell receptors from sequence repertoiresProceedings of the National Academy of Sciences of the United States of America, 2012
- Environmental enteropathy: critical implications of a poorly understood conditionTrends in Molecular Medicine, 2012
- Structure, function and diversity of the healthy human microbiomeNature, 2012
- The Genome of Th17 Cell-Inducing Segmented Filamentous Bacteria Reveals Extensive Auxotrophy and Adaptations to the Intestinal EnvironmentCell Host & Microbe, 2011
- Foxp3+ follicular regulatory T cells control the germinal center responseNature Medicine, 2011
- The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88Nature Immunology, 2010
- Maximum entropy models for antibody diversityProceedings of the National Academy of Sciences of the United States of America, 2010
- Induction of Intestinal Th17 Cells by Segmented Filamentous BacteriaCell, 2009
- The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaProceedings of the National Academy of Sciences of the United States of America, 2008
- Developmental potential in the first 5 years for children in developing countriesThe Lancet, 2007