Diversity Among Memory B Cells: Origin, Consequences, and Utility
- 13 September 2013
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 341 (6151), 1205-1211
- https://doi.org/10.1126/science.1241146
Abstract
Immunological memory is the residuum of a successful immune response that in the B cell lineage comprises long-lived plasma cells and long-lived memory B cells. It is apparent that distinct classes of memory B cells exist, distinguishable by, among other things, immunoglobulin isotype, location, and passage through the germinal center. Some of this variation is due to the nature of the antigen, and some appears to be inherent to the process of forming memory. Here, we consider the heterogeneity in development and phenotype of memory B cells and whether particular functions are partitioned into distinct subsets. We consider also how understanding the details of generating memory may provide opportunities to develop better, functionally targeted vaccines.This publication has 103 references indexed in Scilit:
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