The Death of the Cancer Cell
Open Access
- 30 June 2011
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 71 (13), 4334-4337
- https://doi.org/10.1158/0008-5472.can-11-0639
Abstract
For a century, the perception that there are qualitative differences between a normal cell and a cell belonging to a tumor has dominated discussions aimed at explaining cancer. However, an analysis of the experimental evidence suggests that individual normal cells and individual cancer cells share the same two fundamental behavioral properties, namely, proliferation and motility. Each individual cancer cell carries no recognizable molecules or structures that make them consistently distinguishable from normal cells. Herein, we argue that the differences between normal and cancerous states are instead identifiable at the tissue level of biological organization, and therefore, the search for identification of a cancer cell should be abandoned. Cancer Res; 71(13); 4334–7. ©2011 AACR.Keywords
This publication has 30 references indexed in Scilit:
- Exploring the Genomes of Cancer Cells: Progress and PromiseScience, 2011
- DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine TumorsScience, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancersNature Reviews Cancer, 2010
- Epigenetics in cancerCarcinogenesis: Integrative Cancer Research, 2009
- Theories of carcinogenesis: An emerging perspectiveSeminars in Cancer Biology, 2008
- On physicalism and Downward Causation in Developmental and Cancer BiologyActa Biotheoretica, 2008
- The ground state of embryonic stem cell self-renewalNature, 2008
- Somatic Mutations Are Frequent and Increase with Age in Human Kidney Epithelial CellsHuman Molecular Genetics, 1996
- The streaming liverLiver International, 1985