Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells
- 1 November 1984
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 312 (5993), 418-423
- https://doi.org/10.1038/312418a0
Abstract
It has been found that most immunoglobulin heavy(H)-chain gene diversity (D) segments carry their own 5' transcriptional promoter element. Transcription of rearrangements which use heavy-chain D and joining (J) segments in B-lymphoid cells ultimately leads to the production of a Dmu messenger RNA which contains the DJH segments linked to the mu heavy-chain constant region. If the D is joined to the JH segment in the appropriate translational reading frame, this Dmu mRNA is translated to yield a short Dmu protein with a variable DJH N-terminus.Keywords
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