A Novel Synthesis and Molluscicidal Activity of some Functionally Substituted Pyridine, Pyrido[3,2‐c]pyridazine, and Pyrido[3,2‐c]pyridazino[2′,3′‐a]quinazoline Derivatives

Abstract

Ethyl benzoylacetate reacts with the malononitrile dimer to afford 4-amino-5-benzoyl-2-dicyano methyl-6-hydroxypyridine, which undergoes the coupling reaction with aromatic diazonium salts to afford azo derivatives. These azo derivatives could be cyclized into pyrido[3,2-c]pyridazine and pyrido[3,2-c]pyridazino[2′,3′-a]quinazoline derivatives upon reflux in ethanolic NaOH, presumably via their hydrazo tautomers. The molluscicidal activity of these compounds was evaluated.