Role of Lipid Peroxidation-Derivedα,β-Unsaturated Aldehydes in Vascular Dysfunction

Abstract

Vascular diseases are the most prominent cause of death, and inflammation and vascular dysfunction are key initiators of the pathophysiology of vascular disease. Lipid peroxidation products, such as acrolein and otherα,β-unsaturated aldehydes, have been implicated as mediators of inflammation and vascular dysfunction.α,β-Unsaturated aldehydes are toxic because of their high reactivity with nucleophiles and their ability to form protein and DNA adducts without prior metabolic activation. This strong reactivity leads to electrophilic stress that disrupts normal cellular function. Furthermore,α,β-unsaturated aldehydes are reported to cause endothelial dysfunction by induction of oxidative stress, redox-sensitive mechanisms, and inflammatory changes such as induction of cyclooxygenase-2 and cytokines. This review provides an overview of the effects of lipid peroxidation products,α,β-unsaturated aldehydes, on inflammation and vascular dysfunction.