The Sodium‐Induced Efflux of Calcium from Heart Mitochondria
- 1 October 1976
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 69 (2), 453-462
- https://doi.org/10.1111/j.1432-1033.1976.tb10930.x
Abstract
The interrelations between the transport of Na+ and Ca2+ in rat heart mitochondria were investigated. Na+ induces a partial release of Ca2+ from heart mitochondria; in the presence of ruthenium red the release of Ca2+ by Na+ is complete. The rate of Ca2+ release appears to be a function of [Na+]3 and is stimulated by energy-linked respiration. Ca2+ efflux is also induced by Li+ although Na+ is the preferred cation. The data are consistent with the existence of a system able to catalyze an exchange between Na+ (or Li+) and Ca2+ across the inner membrane of heart mitochondria.This publication has 31 references indexed in Scilit:
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