Occurrence of Coring in Insulin Vials and Possibility of Rubber Piece Contamination by Self-Injection.
- 1 January 2001
- journal article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 121 (6), 459-463
- https://doi.org/10.1248/yakushi.121.459
Abstract
Coring is reported to occur because rubber pieces are shaved off from a rubber stopper when a needle is inserted into the rubber stopper of transfusion liquid formulation. We verified whether coring really occurs in insulin vials of self-injecting patients. We collected insulin cartridges from 30 hospitalized patients and used the primary injection (trial injection), the secondary injection and the cartridge remaining preparation as samples. We observed the rubber pieces using a microscope and measured the shape, number of pieces. The occurrence rate of coring was 73% for the primary injection, 47% for the secondary injection and 97% for the cartridge remaining preparation. The rubber pieces in the primary injection and the secondary injection which went through the needle are mostly in aggregate shape and the rubber pieces in the cartridge remaining preparation which did not go through the needle are mostly in needle-like shape. A number of small rubber pieces are found in both the primary injection and the secondary injection, indicating a high possibility that rubber pieces may be injected under subcutaneous tissue. The coring is considered to occur because needles are repeatedly inserted and rotated at the same spot. It is required to improve the structure to mount a needle to the pen-type injector in future. Coring is a very serious problem from the medical and pharmaceutical points of view. Further study should be made on the implication to latex allergy and lipodystrophy.Keywords
This publication has 4 references indexed in Scilit:
- A Study on Insulin Vial Coring.Japanese Journal of Hospital Pharmacy, 1999
- Compliance Counseling to a Diabetic Patient with Human Insulin-allergy.Japanese Journal of Hospital Pharmacy, 1998
- Immunogenicity and Allergenic Potential of Animal and Human InsulinsDiabetes Care, 1993
- Evaluation and management of insulin allergyJournal of Allergy and Clinical Immunology, 1983