Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart
- 1 May 1996
- journal article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 2 (5), 534-539
- https://doi.org/10.1038/nm0596-534
Abstract
Increased coronary blood vessel development could potentially benefit patients with ischemic heart disease. In a model of stress-induced myocardial ischemia, intracoronary injection of a recombinant adenovirus expressing human fibroblast growth factor-5 (FGF-5) resulted in messenger RNA and protein expression of the transferred gene. Two weeks after gene transfer, regional abnormalities in stress-induced function and blood flow were improved, effects that persisted for 12 weeks. Improved blood flow and function were associated with evidence of angiogenesis. This report documents, for the first time, successful amelioration of abnormalities in myocardial blood flow and function following in vivo gene transfer.Keywords
This publication has 29 references indexed in Scilit:
- Gene Therapy for Vascular Smooth Muscle Cell Proliferation After Arterial InjuryScience, 1994
- Adenoviral-mediated gene transfer to renal tubular cells in vivoKidney International, 1994
- Effects of dobutamine and arbutamine on regional myocardial function in a porcine model of myocardial ischemiaJournal of the American College of Cardiology, 1994
- Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia.JCI Insight, 1993
- Downregulation of cardiac guanosine 5'-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive heart failure.JCI Insight, 1993
- Widespread long-term gene transfer to mouse skeletal muscles and heart.JCI Insight, 1992
- Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning.JCI Insight, 1990
- Detection of human collateral circulation by vasodilation-thallium-201 tomographyThe American Journal of Cardiology, 1990
- Capillary tortuosity and degree of contraction or extension of skeletal musclesMicrovascular Research, 1987
- Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.Circulation, 1978