Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
- 1 January 2006
- journal article
- review article
- Published by Taylor & Francis Ltd in International Journal of Radiation Biology
- Vol. 82 (10), 699-757
- https://doi.org/10.1080/09553000601002324
Abstract
The Cancer Imaging Program of the National Cancer Institute convened a workshop to assess the current status of hypoxia imaging, to assess what is known about the biology of hypoxia as it relates to cancer and cancer therapy, and to define clinical scenarios in which in vivo hypoxia imaging could prove valuable. Hypoxia, or low oxygenation, has emerged as an important factor in tumor biology and response to cancer treatment. It has been correlated with angiogenesis, tumor aggressiveness, local recurrence, and metastasis, and it appears to be a prognostic factor for several cancers, including those of the cervix, head and neck, prostate, pancreas, and brain. The relationship between tumor oxygenation and response to radiation therapy has been well established, but hypoxia also affects and is affected by some chemotherapeutic agents. Although hypoxia is an important aspect of tumor physiology and response to treatment, the lack of simple and efficient methods to measure and image oxygenation hampers further understanding and limits their prognostic usefulness. There is no gold standard for measuring hypoxia; Eppendorf measurement of pO(2) has been used, but this method is invasive. Recent studies have focused on molecular markers of hypoxia, such as hypoxia inducible factor 1 (HIF-1) and carbonic anhydrase isozyme IX (CA-IX), and on developing noninvasive imaging techniques. This workshop yielded recommendations on using hypoxia measurement to identify patients who would respond best to radiation therapy, which would improve treatment planning. This represents a narrow focus, as hypoxia measurement might also prove useful in drug development and in increasing our understanding of tumor biology.Keywords
This publication has 97 references indexed in Scilit:
- Tissue oxygenation in sepsis; new insights fromin vivo EPRNMR in Biomedicine, 2004
- Tumor microvascular changes in antiangiogenic treatment: Assessment by magnetic resonance contrast media of different molecular weightsJournal of Magnetic Resonance Imaging, 2004
- Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection: results of EORTC Translational Research Fund studiesEuropean Journal of Cancer, 2004
- Osteopontin modulates CD44‐dependent chemotaxis of peritoneal macrophages through G‐protein‐coupled receptors: Evidence of a role for an intracellular form of osteopontinJournal of Cellular Physiology, 2003
- Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationshipsJBIC Journal of Biological Inorganic Chemistry, 2002
- pH and ChemotherapyCiba Foundation symposium, 2001
- Physiologic and cytotoxic effects of tirapazamine in tumor-bearing miceRadiation Oncology Investigations, 1997
- Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancerInternational Journal of Cancer, 1996
- Correlation of Cu(PTSM) localization with regional blood flow in the heart and kidneyInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1989
- Electron spin resonance-spin trapping. Detection of superoxide formation during aerobic microsomal reduction of nitro-compoundsBiochemical and Biophysical Research Communications, 1978