Aromatase expression is increased in BRCA1mutation carriers
Open Access
- 16 May 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 9 (1), 148
- https://doi.org/10.1186/1471-2407-9-148
Abstract
Until recently, the molecular mechanisms explaining increased incidence of ovarian and breast cancers in carriers of BRCA1 gene mutations had not been clearly understood. Of significance is the finding that BRCA1 negatively regulates aromatase expression in vitro. Our objective was to characterise aromatase gene (CYP19A1) and its promoter expression in breast adipose and ovarian tissue in BRCA1 mutation carriers and unaffected controls.This publication has 37 references indexed in Scilit:
- Regulation of breast cancer-associated aromatase promotersCancer Letters, 2009
- Characterisation of aromatase expression in the human adipocyte cell line SGBSBreast Cancer Research and Treatment, 2008
- Prostaglandin E2 Induces Breast Cancer–Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose FibroblastsCancer Research, 2007
- Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cellsAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires β-cateninProceedings of the National Academy of Sciences of the United States of America, 2006
- BRCA1 in hormonal carcinogenesis: basic and clinical researchEndocrine-Related Cancer, 2005
- Aromatase and Its Inhibitors: Significance for Breast Cancer TherapyRecent Progress in Hormone Research, 2002
- Perspective: The Ovarian Follicle--A Perspective in 2001Endocrinology, 2001
- Role of direct interaction in BRCA1 inhibition of estrogen receptor activityOncogene, 2001
- No Evidence of a Role for Mutations or Polymorphisms of the Follicle-Stimulating Hormone Receptor in Ovarian Granulosa Cell TumorsJournal of Clinical Endocrinology & Metabolism, 1998