CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19)
- 1 October 2020
- journal article
- letter
- Published by Wiley in Journal of Medical Virology
- Vol. 92 (10), 1721-1723
- https://doi.org/10.1002/jmv.25804
Abstract
Coronaviruses are common human viruses and include the severe acute respiratory syndrome coronavirus (SARS-CoV), the middle east respiratory syndrome coronavirus and the SARS-CoV-2. Coronaviruses mainly bind to transmembrane receptor proteins on the human cell membrane through spike proteins (S-proteins), thus releasing the RNA of the virus into the interior of the host cell to cause an infection. In this article, we discuss the mechanism and production of cyclodextrin-soluble angiotensin-converting enzyme 2 (CD-sACE2) inclusion compounds in the treatment of SARS-CoV-2 infections by blocking S-proteins. On the basis of the current research evidence, we believe that CD-sACE2 inclusion compounds have the potential to treat COVID-19. We hope that our article can provide a theoretical basis for later experiments.Keywords
This publication has 9 references indexed in Scilit:
- Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19Journal of Medical Virology, 2020
- Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathyLaboratory Investigation, 2018
- Mutation and Epistasis in Influenza Virus EvolutionViruses, 2018
- Angiotensin converting enzyme 2 and the kidneyCurrent Opinion in Nephrology and Hypertension, 2016
- From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertensionFrontiers in Physiology, 2014
- Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future PerspectivesMacromolecular Rapid Communications, 2014
- ACE2 alterations in kidney diseaseNephrology Dialysis Transplantation, 2013
- Ectodomain shedding of angiotensin converting enzyme 2 in human airway epitheliaAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2009
- Angiotensin-converting enzyme 2 protects from severe acute lung failureNature, 2005