Formation of Core/Shell Nanoparticles with a Lipid Core and Their Application as a Drug Delivery System
- 17 February 2005
- journal article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 6 (2), 1062-1067
- https://doi.org/10.1021/bm049234r
Abstract
A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)−poly (propylene oxide)−poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.Keywords
This publication has 18 references indexed in Scilit:
- SolEmuls®—novel technology for the formulation of i.v. emulsions with poorly soluble drugsInternational Journal of Pharmaceutics, 2004
- Core/Shell Particles Containing Liquid Cores: Morphology Prediction, Synthesis, and CharacterizationMacromolecules, 2003
- Small-Angle X-ray Scattering Study of the Interaction of Poly(ethylene oxide)-b-Poly(propylene oxide)-b-Poly(ethylene oxide) Triblock Copolymers with Lipid BilayersBiomacromolecules, 2003
- Why Is Trehalose an Exceptional Protein Stabilizer?Published by Elsevier BV ,2003
- Self-Assembly of Mixed Ionic and Zwitterionic Amphiphiles: Associative and Dissociative Interactions between Lamellar PhasesLangmuir, 2002
- Molecular Interactions between a Lipid and an Antineoplastic Drug Paclitaxel (Taxol) within the Lipid Monolayer at the Air/Water InterfaceLangmuir, 2002
- Preparation and Characterization of pH-Responsive Poly(methacrylic acid-g-ethylene glycol) NanospheresMacromolecules, 2002
- Fabrication, characterization and in vitro release of paclitaxel (Taxol®) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiersJournal of Controlled Release, 2001
- In vitro and in vivo degradation of double-walled polymer microspheresJournal of Controlled Release, 1996
- Effect of head-group structure and counterion condensation on phase equilibria in anionic phospholipid-water systems studied by deuterium, sodium-23, and phosphorus-31 NMR and x-ray diffractionBiochemistry, 1991