Influence of Brain and Behavior on the Immune System
- 6 February 1976
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4226), 435-440
- https://doi.org/10.1126/science.1108202
Abstract
It has been shown experimentally that psychosocial processes influence the susceptibility to some infections, to some neoplastic processes, and to some aspects of humoral and cell-mediated immune responses. These psychosocial effects may be related to hypothalamic activity. Reviewing the mechanisms that may be involved in the role of the hypothalamus in immune responses indicates that there is no single mediating factor. Various processes may participate, including the autonomic nervous system and neuroendocrine activity. The research reviewed has been limited primarily to a consideration of the effect of hypothalamic lesions on humoral immune responses. There is some evidence (45, 80) indicating that hypothalamic lesions also modify cell-mediated immune responses. Further research is required to evaluate the effect of the hypothalamus on cell-mediated immunity.This publication has 73 references indexed in Scilit:
- INFLUENCE ON THE INDUCTION AND ELICITATION OF CONTACT‐DERMATITIS IN GUINEA PIGSPsychophysiology, 1971
- PSYCHOSOCIAL FACTORS MODIFYING HOST RESISTANCE TO EXPERIMENTAL INFECTIONS*Annals of the New York Academy of Sciences, 1969
- GENERAL DISCUSSIONAnnals of the New York Academy of Sciences, 1969
- The beta adrenergic theory of the atopic abnormality in bronchial asthmaJournal of Allergy, 1968
- INHIBITORY EFFECT OF ADRENAL GLUCOCORTICOIDS ON HISTAMINE RELEASEThe Japanese Journal of Pharmacology, 1963
- THE EFFECT OF ELECTRIC STItVIULATION OF THE BRAIN ON ANAPHYLACTIC SHOCK IN GUINEA‐PIGAllergy, 1960
- THE INFLUENCE OF THE THYROID GLAND ON HYPKRSENSITIVITY REACTIONS IN ANIMALSAllergy, 1955
- THE INFLUENCE OF THE THYROID GLAND ON HYPERSENSITIVITY REACTIONS IN ANIMALSAllergy, 1955
- A NEUROLOGIC EVALUATION OF THE CUTANEOUS HISTAMINE REACTION 1JCI Insight, 1950
- Über den Einfluß des Zentralnervensystems auf ImmunitätsvorgängeNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1928