Advancing Pig Cloning Technologies Towards Application in Regenerative Medicine
Open Access
- 25 July 2012
- journal article
- review article
- Published by Wiley in Reproduction in Domestic Animals
- Vol. 47 (s4), 120-126
- https://doi.org/10.1111/j.1439-0531.2012.02065.x
Abstract
Regenerative medicine is expected to make a significant contribution by development of novel therapeutic treatments for intractable diseases and for improving the quality of life of patients. Many advances in regenerative medicine, including basic and translational research, have been developed and tested in experimental animals; pigs have played an important role in various aspects of this work. The value of pigs as a model species is being enhanced by the generation of specially designed animals through cloning and genetic modifications, enabling more sophisticated research to be performed and thus accelerating the clinical application of regenerative medicine. This article reviews the significant aspects of the creation and application of cloned and genetically modified pigs in regenerative medicine research and considers the possible future directions of the technology. We also discuss the importance of reproductive biology as an interface between basic science and clinical medicine.Keywords
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