The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia
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Open Access
- 21 April 2011
- journal article
- practice guideline
- Published by American Society of Hematology in Blood
- Vol. 117 (16), 4190-4207
- https://doi.org/10.1182/blood-2010-08-302984
Abstract
Immune thrombocytopenia (ITP) is commonly encountered in clinical practice. In 1996 the American Society of Hematology published a landmark guidance paper designed to assist clinicians in the management of this disorder. Since 1996 there have been numerous advances in the management of both adult and pediatric ITP. These changes mandated an update in the guidelines. This guideline uses a rigorous, evidence-based approach to the location, interpretation, and presentation of the available evidence. We have endeavored to identify, abstract, and present all available methodologically rigorous data informing the treatment of ITP. We provide evidence-based treatment recommendations using the GRADE system in those areas in which such evidence exists. We do not provide evidence in those areas in which evidence is lacking, or is of lower quality—interested readers are referred to a number of recent, consensus-based recommendations for expert opinion in these clinical areas. Our review identified the need for additional studies in many key areas of the therapy of ITP such as comparative studies of “front-line” therapy for ITP, the management of serious bleeding in patients with ITP, and studies that will provide guidance about which therapy should be used as salvage therapy for patients after failure of a first-line intervention.This publication has 151 references indexed in Scilit:
- Toxicities of the Thrombopoietic Growth FactorsSeminars in Hematology, 2010
- Improved quality of life for romiplostim‐treated patients with chronic immune thrombocytopenic purpura: results from two randomized, placebo‐controlled trialsBritish Journal of Haematology, 2009
- Single dose of anti-D immune globulin at 75μg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in childrenThe Journal of Pediatrics, 2006
- Chronic immune thrombocytopentic purpura in children: Assessment of Rituximab treatmentThe Journal of Pediatrics, 2006
- Chronic immune thrombocytopenic purpura in children: Assessment of rituximab treatmentThe Journal of Pediatrics, 2005
- Initial management of immune thrombocytopenic purpura in adults: A randomized controlled trial comparing intermittent anti-D with routine careAmerican Journal of Hematology, 2003
- Initial Treatment of Immune Thrombocytopenic Purpura with High-Dose DexamethasoneThe New England Journal of Medicine, 2003
- Effect of Highly Active Antiretroviral Therapy on Thrombocytopenia in Patients with HIV InfectionThe New England Journal of Medicine, 1999
- Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpuraThe Journal of Pediatrics, 1997
- A trial of high-dose dexamethasone therapy for chronic idiopathic thrombocytopenic purpura in childhoodThe Journal of Pediatrics, 1997