G Protein-Coupled Receptors in Anopheles gambiae

Abstract

We used bioinformatic approaches to identify a total of 276 G protein–coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster . Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.