Tuning in to the Voices: A Multisite fMRI Study of Auditory Hallucinations
Open Access
- 5 November 2008
- journal article
- research article
- Published by Oxford University Press (OUP) in Schizophrenia Bulletin
- Vol. 35 (1), 58-66
- https://doi.org/10.1093/schbul/sbn140
Abstract
Introduction: Auditory hallucinations or voices are experienced by 75% of people diagnosed with schizophrenia. We presumed that auditory cortex of schizophrenia patients who experience hallucinations is tonically “tuned” to internal auditory channels, at the cost of processing external sounds, both speech and nonspeech. Accordingly, we predicted that patients who hallucinate would show less auditory cortical activation to external acoustic stimuli than patients who did not. Methods: At 9 Functional Imaging Biomedical Informatics Research Network (FBIRN) sites, whole-brain images from 106 patients and 111 healthy comparison subjects were collected while subjects performed an auditory target detection task. Data were processed with the FBIRN processing stream. A region of interest analysis extracted activation values from primary (BA41) and secondary auditory cortex (BA42), auditory association cortex (BA22), and middle temporal gyrus (BA21). Patients were sorted into hallucinators (n = 66) and nonhallucinators (n = 40) based on symptom ratings done during the previous week. Results: Hallucinators had less activation to probe tones in left primary auditory cortex (BA41) than nonhallucinators. This effect was not seen on the right. Discussion: Although “voices” are the anticipated sensory experience, it appears that even primary auditory cortex is “turned on” and “tuned in” to process internal acoustic information at the cost of processing external sounds. Although this study was not designed to probe cortical competition for auditory resources, we were able to take advantage of the data and find significant effects, perhaps because of the power afforded by such a large sample.Keywords
This publication has 22 references indexed in Scilit:
- The hallucinating brain: A review of structural and functional neuroimaging studies of hallucinationsNeuroscience & Biobehavioral Reviews, 2007
- The cortical organization of speech processingNature Reviews Neuroscience, 2007
- Competition for neuronal resources: how hallucinations make themselves heardThe British Journal of Psychiatry, 2007
- Reducing inter-scanner variability of activation in a multicenter fMRI study: Role of smoothness equalizationNeuroImage, 2006
- Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patientsSchizophrenia Research, 2006
- An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interestNeuroImage, 2006
- Cortical Surface-Based Analysis: I. Segmentation and Surface ReconstructionNeuroImage, 1999
- The auditory hallucination: a phenomenological surveyPsychological Medicine, 1996
- A functional neuroanatomy of hallucinations in schizophreniaNature, 1995
- The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of actionPsychological Medicine, 1987