The Neural Bases of Word Encoding and Retrieval: A fMRI-Guided Transcranial Magnetic Stimulation Study
Open Access
- 12 December 2009
- journal article
- Published by Springer Science and Business Media LLC in Brain Topography
- Vol. 22 (4), 318-332
- https://doi.org/10.1007/s10548-009-0126-1
Abstract
There is evidence that the human prefrontal cortex is asymmetrically involved in long-term episodic memory processing. Moreover, abstract and concrete words processing has been reported to differentially involve prefrontal and parietal areas. We implemented a two-stages functional magnetic resonance imaging (fMRI)-repetitive transcranial magnetic stimulation (rTMS) paradigm to investigate the role of the dorsolateral prefrontal cortices (DLPFCs) and parietal cortices (PARCs) in encoding and retrieval of abstract and concrete words. Using this paradigm we could select areas to be stimulated on the basis of single-subject (SS) anatomical and functional data, investigating the usefulness of this integration approach. With respect to fMRI, abstract and concrete words differed only for a greater left fusiform gyrus activation for concrete words. In turn, significant rTMS effects were found, but only for the retrieval of abstract words. Consistent with previous findings, repetitive stimulation of the right DLPFC had a specific impact on episodic retrieval. Memory retrieval performance was also disrupted when rTMS was applied to the left PARC. Finally, we found a significant positive correlation between the effect sizes of SS right PARC activations for abstract word retrieval and the consequent rTMS interference effects. Taken together these data provide for the first time evidence that also the PARC has a necessary role in episodic retrieval of abstract words. Importantly, from a methodological perspective, our data demonstrate that fMRI-guided rTMS with a SS approach provides a powerful tool to investigate the neural underpinnings of cognitive functions.Keywords
This publication has 44 references indexed in Scilit:
- The role of the prefrontal cortex in sentence comprehension: An rTMS studyCortex, 2008
- Localization of load sensitivity of working memory storage: Quantitatively and qualitatively discrepant results yielded by single-subject and group-averaged approaches to fMRI group analysisNeuroImage, 2007
- Direct evidence for a prefrontal contribution to the control of proactive interference in verbal working memoryProceedings of the National Academy of Sciences of the United States of America, 2006
- The effect of word concreteness on recognition memoryNeuroImage, 2006
- Prefrontal and parietal cortex in human episodic memory: an interference study by repetitive transcranial magnetic stimulationEuropean Journal of Neuroscience, 2006
- Combining transcranial magnetic stimulation and functional imaging in cognitive brain research: possibilities and limitationsBrain Research Reviews, 2003
- Modulation of a brain–behavior relationship in verbal working memory by rTMSCognitive Brain Research, 2003
- Bilateral parieto‐frontal network for verbal working memory: an interference approach using repetitive transcranial magnetic stimulation (rTMS)European Journal of Neuroscience, 2002
- Classical and Bayesian Inference in Neuroimaging: ApplicationsNeuroImage, 2002
- Prefontal cortex in long-term memory: an “interference” approach using magnetic stimulationNature Neuroscience, 2001