Serum Uric Acid Levels in Obese Children and Adolescents: Linkage to Testosterone Levels and Pre-metabolic Syndrome
- 1 January 2003
- journal article
- research article
- Published by Walter de Gruyter GmbH in Journal of Pediatric Endocrinology and Metabolism
- Vol. 16 (9), 1225-1232
- https://doi.org/10.1515/jpem.2003.16.9.1225
Abstract
Hyperuricemia is part of the "metabolic syndrome". The aim of this study was to investigate the regulation and role of serum uric acid in the cardiovascular risk factor profile of obese children and adolescents. Serum levels of uric acid and selected risk factors and hormones were determined in 269 children aged 10.0-15.9 years with a BMI >90th percentile (mean 24.0 kg/m2, SD 5.43). Stepwise regression adjusted for age and sex revealed that testosterone (p < 0.0001), BMI (p < 0.0001), systolic blood pressure (p < 0.0017), triglycerides (p < 0.0345) and cholesterol/HDL ratio (p < 0.0393) were positively correlated with serum uric acid and accounted for 42.1% of the variance. Additional regression models with the same set of variables indicated that uric acid contributed significantly to levels of cholesterol/HDL, total cholesterol, BMI and systolic blood pressure, respectively. These results suggest a not yet described impact of androgens in the regulation of serum uric acid in obese children and adolescents. Furthermore, they show that uric acid is a reliable indicator for the "pre-metabolic syndrome" in obese youths.Keywords
This publication has 16 references indexed in Scilit:
- Heart Rate Variability in Obese Children: Relations to Total Body and Visceral Adiposity, and Changes with Physical Training and DetrainingObesity Research, 2000
- The role of central fat distribution in coronary artery disease in obesity: comparison of nondiabetic obese, diabetic obese, and normal weight subjectsInternational Journal of Obesity, 1999
- Serum uric acid and related factors in 500 hospitalized subjectsMetabolism, 1996
- Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reductionJournal of Clinical Endocrinology & Metabolism, 1995
- The influence of testosterone on purine nucleotide metabolism in rat liverLife Sciences, 1995
- Uric acid homeostasis in lean and obese girls during pubertal developmentMetabolism, 1994
- The association of the ratio of waist to hip girth with blood pressure, serum cholesterol and serum uric acid in children and youths aged 6–17 yearsJournal of Chronic Diseases, 1987
- Blood pressure in childhood and adolescence. Results from an international collaborative study on juvenile hypertensionaActa Paediatrica, 1985
- Influence of persistent obesity in children on cardiovascular risk factors: the Bogalusa Heart Study.Circulation, 1984
- Diagnosis and clinical significance of parainfluenza virus infections in childrenArchives of Disease in Childhood, 1974