Evidence for a Trophic Action of the Glycoprotein Hormone α‐Subunit in Rat Pituitary
- 1 February 1996
- journal article
- Published by Wiley in Journal of Neuroendocrinology
- Vol. 8 (2), 99-102
- https://doi.org/10.1111/j.1365-2826.1996.tb00829.x
Abstract
The effect of the alpha-subunit of luteinizing hormone (LH alpha) on lactotroph growth in 14-day-old rat pituitary was studied in vitro using a reaggregate pituitary cell culture system. LH alpha significantly expanded both the total population of cells expressing prolactin mRNA and the number of [3H]thymidine incorporating prolactin mRNA expressing cells. No such effect could be elicited by LH. Both effects were inhibited by simultaneous addition of an anti-LH alpha antiserum but not by normal rabbit serum. Anti-LH alpha antiserum added alone to the cultures caused a small decrease in the number of prolactin mRNA expressing cells and in [3H]thymidine labelling of the latter. It is concluded that LH alpha may be a trophic factor of lactotrophs not only during fetal development, as suggested by others previously, but also during the rapid expansion of this cell type during postnatal life in the rat.Keywords
This publication has 27 references indexed in Scilit:
- Interaction of LHRH with growth hormone-releasing factor-dependent and -independent postnatal development of somatotrophs in rat pituitary cell aggregatesJournal of Molecular Endocrinology, 1995
- In vitro evidence that an 11-kilodalton N-terminal fragment of proopiomelanocortin is a growth factor specifically stimulating the development of lactotrophs in rat pituitary during postnatal lifeEndocrinology, 1994
- In vitro evidence that LHRH stimulates the recruitment of prolactin mRNA-expressing cells during the postnatal period in the ratJournal of Molecular Endocrinology, 1994
- Early Expression of the Glycoprotein Hormone Alpha-Subunit in the Pars Tuberalis of the Rat Pituitary Gland during OntogenesisNeuroendocrinology, 1993
- Luteinizing hormone-releasing hormone and neuropeptide Y influence deoxyribonucleic acid replication in three anterior pituitary cell types. Evidence for mediation by growth factors released from gonadotrophsEndocrinology, 1992
- Effects of gonadotrophin releasing hormone antagonist and agonist on the pulsatile release of gonadotrophins and α‐subunit in postmenopausal women*Clinical Endocrinology, 1991
- Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.Genes & Development, 1990
- Induction of Pituitary Lactotrope Differentiation by Luteinizing Hormone α SubunitScience, 1984
- Pure Alpha-Secreting Pituitary AdenomasNew England Journal of Medicine, 1981