iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
Open Access
- 1 October 2009
- journal article
- Published by Elsevier BV
- Vol. 284 (43), 29746-29756
- https://doi.org/10.1074/jbc.m109.046805
Abstract
No abstract availableKeywords
This publication has 52 references indexed in Scilit:
- Lactimidomycin, Iso-migrastatin and Related Glutarimide-Containing 12-Membered Macrolides Are Extremely Potent Inhibitors of Cell MigrationJournal of the American Chemical Society, 2009
- Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potencyBioorganic & Medicinal Chemistry Letters, 2008
- Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous HostsJournal of Bacteriology, 2008
- Nontoxic Strains of Cyanobacteria Are the Result of Major Gene Deletion Events Induced by a Transposable ElementMolecular Biology and Evolution, 2008
- Polyketide Biosynthesis beyond the Type I, II, and III Polyketide Synthase Paradigms: A Progress ReportPublished by American Chemical Society (ACS) ,2007
- Thermolysis of Isomigrastatin and Its Congeners via [3,3]-Sigmatropic Rearrangement: A New Route to the Synthesis of Migrastatin and Its AnaloguesOrganic Letters, 2006
- Structural and Functional Characterization of Three Polyketide Synthase Gene Clusters in Bacillus amyloliquefaciens FZB 42Journal of Bacteriology, 2006
- Streptomyces inside-out: a new perspective on the bacteria that provide us with antibioticsPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2006
- Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthaseGene, 1996
- The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of streptomycesCell, 1991