Smurf control in bone cells
- 5 April 2010
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 110 (3), 554-563
- https://doi.org/10.1002/jcb.22586
Abstract
The homologous to the E6‐assosiated protein carboxyl terminus (HECT) domain E3 ubiquitin ligase Smurf1 is the first E3 ligase to be implicated in regulating bone cell function. The involvement of Smurf1 in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review highlights recent works exploring Smurf‐regulated biological processes in bone cells and highlights recent discoveries surrounding the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Moreover, we discuss the relevance of targeting the HECT E3s through the development of small‐molecule inhibitors as an anticancer therapeutic strategy. J. Cell. Biochem. 110: 554–563, 2010.Keywords
This publication has 85 references indexed in Scilit:
- Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradationJournal of Bone and Mineral Research, 2010
- Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β SignalingMolecular Cell, 2009
- Development and optimization of a cell‐based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein‐2 activityCell Biochemistry and Function, 2009
- Smurf2 induces degradation of GSK-3β and upregulates β-catenin in chondrocytes: A potential mechanism for Smurf2-induced degeneration of articular cartilageExperimental Cell Research, 2009
- A Homozygous Mutation in Human PRICKLE1 Causes an Autosomal-Recessive Progressive Myoclonus Epilepsy-Ataxia SyndromeAmerican Journal of Human Genetics, 2008
- Induction of an osteoarthritis‐like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic miceArthritis & Rheumatism, 2008
- The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer DevelopmentCancer Cell, 2008
- TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiationBiochemical and Biophysical Research Communications, 2007
- Regulation of cancer cell migration and bone metastasis by RANKLNature, 2006
- Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin ChainCell, 2000