Building a staircase to precision medicine for biliary tract cancer
- 27 August 2015
- journal article
- editorial
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 47 (9), 967-968
- https://doi.org/10.1038/ng.3386
Abstract
A new study has conducted a comprehensive exome and transcriptome analysis of a large number of intrahepatic, perihilar and distal cholangiocarcinomas and gallbladder cancers in Japanese patients. This study identifies many new alterations, confirms genetic differences in these distinct subtypes of biliary tract cancer and demonstrates that approximately 40% of described genetic aberrations are potentially targetable.Keywords
This publication has 11 references indexed in Scilit:
- Genomic spectra of biliary tract cancerNature Genetics, 2015
- Mutation Profiling in Cholangiocarcinoma: Prognostic and Therapeutic ImplicationsPLOS ONE, 2014
- Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular CarcinomaScience, 2014
- CholangiocarcinomaThe Lancet, 2014
- Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic CholangiocarcinomaPLoS Genetics, 2014
- Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinomaHepatology, 2013
- High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesionsNature Communications, 2013
- Identification of Targetable FGFR Gene Fusions in Diverse CancersCancer Discovery, 2013
- Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different OutcomesGastroenterology, 2013
- Pattern of chromosomal aberrations in primary liver cancers identified by comparative genomic hybridizationHuman Pathology, 2009