Childhood Cryptosporidiosis Is Associated with a Persistent Systemic Inflammatory Response
Open Access
- 1 September 2006
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 43 (5), 604-608
- https://doi.org/10.1086/506565
Abstract
Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor-α systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor-α was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.This publication has 20 references indexed in Scilit:
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