Prednisone for chronic active liver disease: dose titration, standard dose, and combination with azathioprine compared.
Open Access
- 1 November 1975
- Vol. 16 (11), 876-883
- https://doi.org/10.1136/gut.16.11.876
Abstract
The pathology of the alimentary tracts of nine patients dying of Salmonella typhimurium infection is reviewed. Two patients had previous gastric operations, supporting previous reports that such patients are more susceptible to food poisoning. Four had no parietal (oxyntic) cells in the gastric mucosa, suggesting hypo- or anacidity. Only one had acute gastritis. None had acute enteritis, but in half of the patients, subtle histological changes suggested an 'enteropathy'. Acute diffuse colitis with abundant crypt abscesses, without stromal abscesses in the lamina propria, was the most constant finding and reparative features started very early, and occurred in later deaths. Under ideal circumstances this crypt abscess is readily distinguished from that of idiopathic ulcerative colitis, but can be confused with the crypt abscess of acute bacillary (sonne) dysentery. While the florid colonic changes may have settled in the late deaths, active inflammation is commonly present in the appendix mucosa on histology. The pathology of the alimentary tract in S typhimurium infection differs from that of S typhi and S paratyphi infections. There is little evidence of gastroenteritis, although subtle changes occur in the stomach and small intestine. The features are those of acute diffuse colitis with histological appendicitis, distinguishable from idiopathic ulcerative colitis.Keywords
This publication has 14 references indexed in Scilit:
- CONTROLLED TRIAL OF PREDNISONE AND AZATHIOPRINE IN ACTIVE CHRONIC HEPATITISThe Lancet, 1973
- MALIGNANT TUMORS ARISING DE NOVO IN IMMUNOSUPPRESSED ORGAN TRANSPLANT RECIPIENTSTransplantation, 1972
- Reduction of toxicity of corticosteroid therapy after renal transplantationAmerican Journal Of Medicine, 1972
- Chronic active liver diseaseHuman Pathology, 1972
- Observer error and sampling variability tested in evaluation of hepatitis and cirrhosis by liver biopsyDigestive Diseases and Sciences, 1971
- Controlled Prospective Trial of Corticosteroid Therapy in Active Chronic HepatitisQJM: An International Journal of Medicine, 1971
- PROGNOSIS OF CHRONIC PERSISTENT HEPATITISThe Lancet, 1970
- Long-term results of therapy in patients with chronic liver disease associated with hypergammaglobulinemiaAmerican Journal Of Medicine, 1969
- Chronic hepatitis: effect of prolonged suppressive treatment and comparison of azathioprine with prednisolone.1968
- Studies on an Intermittent Corticosteroid Dosage RegimenNew England Journal of Medicine, 1963