Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography
- 10 March 2010
- journal article
- Published by Pleiades Publishing Ltd in Laser Physics
- Vol. 20 (4), 891-899
- https://doi.org/10.1134/s1054660x10070029
Abstract
We have applied a compact low power rapid scanning Doppler Optical Coherence Tomography system to monitor multi-dimensional velocity profiles within the complex vessels and simultaneous real-time non-invasive imaging of skin tissues morphology in vivo, in the wavelength range of 1.3–1.5 nm. Optical clearing of skin tissues has been utilized to achieve depth of OCT images up to 1.7 mm. Current approach enables applying low-power (0.4–0.5 mW) and low-noise broadband near-infrared light sources and obtaining OCT images with down to 12 μm spatial resolution. Two-dimensional time-domain OCT images of complex flow velocity profiles in blood vessel phantom and in vivo subcutaneous human skin tissues are presented. The effect of optical clearing on in vivo images is demonstrated and discussed.Keywords
This publication has 49 references indexed in Scilit:
- Handbook of Coherent Domain Optical MethodsPublished by Springer Science and Business Media LLC ,2004
- Real-time multi-functional optical coherence tomographyOptics Express, 2003
- Optical coherence tomography - principles and applicationsReports on Progress in Physics, 2003
- Observations of birefringence in tissues from optic-fibre-based optical coherence tomographyMeasurement Science and Technology, 2002
- Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomographyOptics Letters, 2002
- Handbook of Optical Coherence TomographyPublished by Informa UK Limited ,2001
- Optical coherence tomography (OCT): a reviewIEEE Journal of Selected Topics in Quantum Electronics, 1999
- Optical Coherence TomographyScience, 1991
- Guided-wave reflectometry with micrometer resolutionApplied Optics, 1987
- Optical coherence-domain reflectometry: a new optical evaluation techniqueOptics Letters, 1987