Fibrinogen γ′ in Ischemic Stroke
- 1 March 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 39 (3), 1033-1035
- https://doi.org/10.1161/strokeaha.107.495499
Abstract
Background and Purpose— To determine the contribution of fibrinogen γ′ levels and FGG haplotypes to ischemic stroke. Methods— Associations between fibrinogen γ′ levels, fibrinogen γ′/total fibrinogen ratio, and FGG haplotypes with the risk of ischemic stroke were determined in 124 cases and 125 controls. Results— Fibrinogen γ′/total fibrinogen ratio was higher in patients than in controls during the acute phase of the stroke and lower in the convalescent phase 3 months after the stroke. FGG haplotype 3 (H3) was associated with a reduced risk of ischemic stroke (odds ratio 0.60; 95% CI, 0.38 to 0.94), but not with the fibrinogen γ′/total fibrinogen ratio. In contrast, FGG-H2 was associated with a decreased fibrinogen γ′/total fibrinogen ratio, but not with risk of stroke. Conclusions— Fibrinogen γ′/total fibrinogen ratio is associated with ischemic stroke, especially in the acute phase of the disease. In addition, FGG-H3 haplotype appears to be protective against ischemic stroke.This publication has 7 references indexed in Scilit:
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