14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease
Open Access
- 18 July 2019
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 20 (14), 3518
- https://doi.org/10.3390/ijms20143518
Abstract
14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds of target proteins. Also, 14-3-3 proteins act as molecular chaperones, preventing the aggregation of unfolded proteins under conditions of cellular stress. Furthermore, 14-3-3 proteins have been shown to have similar expression patterns in tumors, aging, and neurodegenerative diseases. Therefore, we put forward the idea that the adaptor activity and chaperone-like activity of 14-3-3 proteins might play a substantial role in the above-mentioned conditions. Interestingly, 14-3-3 proteins are considered to be standing at the crossroads of cancer, aging, and age-related neurodegenerative diseases. There are great possibilities to improve the above-mentioned diseases and conditions through intervention in the activity of the 14-3-3 protein family.Keywords
Funding Information
- National Natural Science Foundation of China (31771338, 81701392)
This publication has 134 references indexed in Scilit:
- 14‐3‐3ɛ/ζ Affects the stability of δ‐catenin and regulates δ‐catenin‐induced dendrogenesisFEBS Open Bio, 2012
- Monomeric 14-3-3ζ Has a Chaperone-Like Activity and Is Stabilized by Phosphorylated HspB6Biochemistry, 2012
- Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancerGenes, Chromosomes and Cancer, 2011
- Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunitOncogene, 2011
- TOR signaling never gets old: Aging, longevity and TORC1 activityAgeing Research Reviews, 2011
- Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's diseaseCell Death & Disease, 2010
- 14-3-3ζ Contributes to Tyrosine Hydroxylase Activity in MN9D CellsJournal of Biological Chemistry, 2009
- The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer developmentTrends in Cell Biology, 2009
- Structural basis for protein–protein interactions in the 14-3-3 protein familyProceedings of the National Academy of Sciences of the United States of America, 2006
- C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life SpanCell, 2006