Time-dependent 3D simulations of the hemodynamics in a stented coronary artery
- 1 March 2007
- journal article
- Published by IOP Publishing in Biomedical Materials
- Vol. 2 (1), S28-S37
- https://doi.org/10.1088/1748-6041/2/1/s05
Abstract
Stenting is becoming the major interventional cardiology procedure worldwide. However restenosis remains a major limitation to the effectiveness of stents. Alterations to the local hemodynamics in the stented segment of the artery could be a potential factor in the development of in-stent restenosis. The characterization of wall shear stress and of blood flow patterns in a stented artery is therefore necessary for a good understanding of the role of hemodynamics in the development of in-stent restenosis. We have used a time-dependent 3D numerical model of a stented coronary artery to study the characteristics of the blood flow and the shear stress distribution. Our results show that the presence of the stent produces significant secondary flow that is limited to an annulus in the near wall region. Low shear stress zones were localized in the vicinity of the struts while the tips of the struts exhibited high values of shear stress. These results support the hypothesis that local hemodynamics may affect the development of in-stent restenosis and could influence the choice of stent geometries for future stent designs.Keywords
This publication has 29 references indexed in Scilit:
- Stent design related neointimal tissue proliferation in human coronary arteries; an intravascular ultrasound studyPublished by Oxford University Press (OUP) ,2001
- Restenosis after coronary placement of various stent typesThe American Journal of Cardiology, 2001
- Association Between Intima-Media Thickness and Wall Shear Stress in Common Carotid Arteries in Healthy Male SubjectsCirculation, 1996
- Pulsatile Flow in the Human Left Coronary Artery Bifurcation: Average ConditionsJournal of Biomechanical Engineering, 1996
- Endovascular Stent Design Dictates Experimental Restenosis and ThrombosisCirculation, 1995
- Flow instabilities induced by coronary artery stents: Assessment with an in vitro pulse duplicatorJournal of Biomechanics, 1995
- Effects of stent design and serum cholesterol level on the restenosis rate in atherosclerotic rabbitsAmerican Heart Journal, 1993
- Pulsatile Flow Visualization in the Abdominal Aorta Under Differing Physiologic Conditions: Implications for Increased Susceptibility to AtherosclerosisJournal of Biomechanical Engineering, 1992
- Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
- Correlation between intimal thickness and fluid shear in human arteriesAtherosclerosis, 1981