Evolution of the Fgf and Fgfr gene families
Top Cited Papers
- 1 November 2004
- journal article
- review article
- Published by Elsevier BV in Trends in Genetics
- Vol. 20 (11), 563-569
- https://doi.org/10.1016/j.tig.2004.08.007
Abstract
Fibroblast growth factors (Fgfs) and Fgf receptors (Fgfrs) comprise a signaling system that is conserved throughout metazoan evolution. Twenty-two Fgfs and four Fgfrs have been identified in humans and mice. During evolution, the Fgf family appears to have expanded in two phases. In the first phase, during early metazoan evolution, Fgfs expanded from two or three to six genes by gene duplication. In the second phase, during the evolution of early vertebrates, the Fgf family expanded by two large-scale gen(om)e duplications. By contrast, the Fgfr family has expanded only in the second phase. However, the acquisition of alternative splicing by Fgfrs has increased their functional diversity. The mechanisms that regulate alternative splicing have been conserved since the divergences of echinoderms and vertebrates. The expansion of the Fgf and Fgfr gene families has enabled this signaling system to acquire functional diversity and, therefore, an almost ubiquitous involvement in developmental and physiological processes.Keywords
This publication has 25 references indexed in Scilit:
- Genome sequence of the Brown Norway rat yields insights into mammalian evolutionNature, 2004
- pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryosGenes & Development, 2004
- Phylogenetic analyses alone are insufficient to determine whether genome duplication(s) occurred during early vertebrate evolutionJournal of Experimental Zoology, 2003
- Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genesRNA, 2003
- Sequence First. Ask Questions Later.Cell, 2002
- Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripesScience, 2002
- FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesisGenes & Development, 2002
- Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18Genes & Development, 2002
- Gene Family Evolution and Homology: Genomics Meets PhylogeneticsAnnual Review of Genomics and Human Genetics, 2000
- FGFs, heparan sulfate and FGFRs: complex interactions essential for developmentBioEssays, 2000