Determination of Trace Amounts of Chemical Warfare Agent Degradation Products in Decontamination Solutions with NMR Spectroscopy
- 1 November 2007
- journal article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 79 (23), 9098-9106
- https://doi.org/10.1021/ac0713196
Abstract
Decontamination solutions are used for an efficient detoxification of chemical warfare agents (CWAs). As these solutions can be composed of strong alkaline chemicals with hydrolyzing and oxidizing properties, the analysis of CWA degradation products in trace levels from these solutions imposes a challenge for any analytical technique. Here, we present results of application of nuclear magnetic resonance spectroscopy for analysis of trace amounts of CWA degradation products in several untreated decontamination solutions. Degradation products of the nerve agents sarin, soman, and VX were selectively monitored with substantially reduced interference of background signals by 1D 1H−31P heteronuclear single quantum coherence (HSQC) spectrometry. The detection limit of the chemicals was at the low part-per-million level (2−10 μg/mL) in all studied solutions. In addition, the concentration of the degradation products was obtained with sufficient confidence with external standards.Keywords
This publication has 17 references indexed in Scilit:
- Screening and Identification of Organophosphorus Compounds Related to the Chemical Weapons Convention with 1D and 2D NMR SpectroscopyAnalytical Chemistry, 2006
- Quantitative 1H NMR with External Standards: Use in Preparation of Calibration Solutions for Algal Toxins and Other Natural ProductsAnalytical Chemistry, 2005
- Application of Nonselective 1D 1H−31P Inverse NMR Spectroscopy to the Screening of Solutions for the Presence of Organophosphorus Compounds Related to the Chemical Weapons ConventionAnalytical Chemistry, 2003
- Quantitative 2D HSQC (Q-HSQC) via Suppression of J-Dependence of Polarization Transfer in NMR Spectroscopy: Application to Wood LigninJournal of the American Chemical Society, 2003
- Quantitative determination of aliphatic hydrocarbon compounds by 2D NMRMagnetic Resonance in Chemistry, 2002
- Method Performance and Validation for Quantitative Analysis by 1H and 31P NMR Spectroscopy. Applications to Analytical Standards and Agricultural ChemicalsAnalytical Chemistry, 1998
- Application of Two-Dimensional 1H−31P Inverse NMR Spectroscopy to the Detection of Trace Amounts of Organophosphorus Compounds Related to the Chemical Weapons ConventionAnalytical Chemistry, 1997
- Detection of Trace Amounts of Chemical Warfare Agents and Related Compounds in Rubber, Paint, and Soil Samples by 1H and 31P{1H} NMR SpectroscopyAnalytical Chemistry, 1996
- An approach to the design of molecular solids. The ureylene dicarboxylic acidsJournal of the American Chemical Society, 1990
- Displacements and Nuclear Substitutions on HydroxypyrazinesJournal of the American Chemical Society, 1956