Systematic Review and Meta-Analysis of 16 Randomized Clinical Trials of Radix Astragali and Its Prescriptions for Diabetic Retinopathy
Open Access
- 1 January 2013
- journal article
- review article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2013, 1-13
- https://doi.org/10.1155/2013/762783
Abstract
Objective. To evaluate the efficacy and safety of radix astragali and its prescriptions for diabetic retinopathy.Methods. A computer-based online and manual search was conducted for randomized controlled trials addressing radix astragali and its prescriptions for diabetic retinopathy.Results. 16 RCTs involving 977 subjects and 1586 eyes were identified. Meta-analysis indicated that the effect of radix astragali and its prescriptions in improving visual acuity and fundus manifestations, lowering FBG, TG, plasma viscosity, and RAI, was superior to that of control group (WMD or OR 0.20, 0.27, −0.26, −0.36, −0.93, −1.27; 95% CI [0.09, 0.30], [0.17, 0.40], [−0.51, 0.00], [−0.60, −0.12], [−1.67, −0.20], [−2.35, −0.19];, resp.). In contrary, the efficacy of radix astragali and its prescriptions was not superior to those of control group in descending HbA1C and TC with WMD 0.45, −0.96 and 95% CI [−1.00, 1.90], [−2.19, 0.27],, respectively. GRADE software suggested that the studies were of low methodological quality.Conclusion. Radix astragali and its prescriptions were superior to other treatments for diabetic retinopathy in terms of improving visual acuity and fundus manifestations, reducing FBG, TG, RAI, and plasma viscosity. The evaluated studies were of low methodological quality, indicating that the previous findings should be read with care.
Keywords
Funding Information
- National High Technology Research and Development Program of China (2006BAI04A0401)
This publication has 31 references indexed in Scilit:
- Diabetic retinopathy and inflammation: Novel therapeutic targetsMiddle East African Journal of Ophthalmology, 2012
- The worldwide epidemic of diabetic retinopathyIndian Journal Of Ophthalmology, 2012
- Microvascular complications assessment in adolescents with 2- to 5-yr duration of type 1 diabetes from 1990 to 2006Pediatric Diabetes, 2011
- Effect of Intravitreal Bevacizumab on Vascular Endothelial Growth Factor Expression in Patients with Proliferative Diabetic RetinopathyYonsei Medical Journal, 2011
- Intravitreal Bevacizumab (Avastin) for Diabetic Retinopathy: The 2010 GLADAOF LectureJournal of Ophthalmology, 2011
- Effects of Medical Therapies on Retinopathy Progression in Type 2 DiabetesNew England Journal of Medicine, 2010
- Diabetic retinopathyThe Lancet, 2010
- Effects of Intensive Blood-Pressure Control in Type 2 Diabetes MellitusNew England Journal of Medicine, 2010
- Effects of Combination Lipid Therapy in Type 2 Diabetes MellitusNew England Journal of Medicine, 2010
- A proposed new classification for diabetic retinopathy: The concept of primary and secondary vitreopathyIndian Journal of Ophthalmology, 2008