Simultaneous squamous cell carcinoma with primary malignant fibrous histiocytoma of the larynx: A case report

Abstract

Simultaneous multiple malignancies of the larynx are rarely reported. In this study, we describe a case with simultaneous laryngeal, moderately differentiated squamous cell carcinoma (SCC) and primary malignant fibrous histiocytoma (MFH) in a patient presenting with progressive hoarseness and without cervical lymphadenopathy. The clinical presentation, intraoperative findings, radiographic images and pathology slides are presented. The diagnosis was confirmed using H&E staining and immunohistochemical testing. A partial laryngectomy with bilateral neck selective dissection was performed. The patient survived for more than 46 months following surgery without recurrence or metastasis. To our knowledge, this is the first report of a case with simultaneous laryngeal SCC and primary MFH in the English literature. The results indicate that the markers used to assess the prognosis of MFH may also be used to assess simultaneous laryngeal SCC and primary MFH, and that laryngectomy to preserve function may be performed in early-stage patients.