Myelin/Oligodendrocyte Glycoprotein-Specific T-Cells Induce Severe Optic Neuritis in the C57Bl/6 Mouse

Abstract

Purpose. The optic nerve is a common site of tissue damage in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). To determine the relationship between optic neuritis (ON) and EAE, we examined the incidence of ON in C57BL/6 (B6) mice immunized with a myelin oligodendrocyte/glycoprotein (MOG)–derived peptide or injected with MOG-specific T cells, which are known to induce EAE.