The Cellular Functions of Small GTP-Binding Proteins
- 10 August 1990
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 249 (4969), 635-640
- https://doi.org/10.1126/science.2116664
Abstract
A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30 Ras-related small guanosine triphosphate (GTP)-binding proteins are known, and from yeast to man they appear to be involved in controlling a diverse set of essential cellular functions including growth, differentiation, cytoskeletal organization, and intracellular vesicle transport and secretion.Keywords
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