Lipidomics: coming to grips with lipid diversity
Top Cited Papers
- 7 July 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 11 (8), 593-598
- https://doi.org/10.1038/nrm2934
Abstract
Although lipids are biomolecules with seemingly simple chemical structures, the molecular composition of the cellular lipidome is complex and, currently, poorly understood. The exact mechanisms of how compositional complexity affects cell homeostasis and its regulation also remain unclear. This emerging field is developing sensitive mass spectrometry technologies for the quantitative characterization of the lipidome. Here, we argue that lipidomics will become an essential tool kit in cell and developmental biology, molecular medicine and nutrition.Keywords
This publication has 61 references indexed in Scilit:
- Structural Characterization of Phospholipids and Peptides Directly from Tissue Sections by MALDI Traveling-Wave Ion Mobility-Mass SpectrometryAnalytical Chemistry, 2010
- Lipidomics: a mass spectrometry based systems level analysis of cellular lipidsCurrent Opinion in Chemical Biology, 2009
- Targeted lipidomic analysis of oxysterols in the embryonic central nervous systemMolecular BioSystems, 2009
- Intracellular sterol dynamicsBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009
- Lipidomics joins the omics evolutionProceedings of the National Academy of Sciences of the United States of America, 2009
- Global analysis of the yeast lipidome by quantitative shotgun mass spectrometryProceedings of the National Academy of Sciences of the United States of America, 2009
- Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signallingThe EMBO Journal, 2009
- A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorStructure, 2008
- Membrane lipids: where they are and how they behaveNature Reviews Molecular Cell Biology, 2008
- Synthesis and medical applications of oligosaccharidesNature, 2007