Clinical utility of multipolar ablation with a 3‐D simulator system for patients with liver cancer
- 27 February 2017
- journal article
- research article
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 32 (11), 1852-1858
- https://doi.org/10.1111/jgh.13772
Abstract
Background and Aim The aim of this study is to confirm the efficacy of multipolar ablation with a new simulator system, three‐dimensional (3‐D) sim‐Navigator, for patients with hepatocellular carcinoma by assessing relapse‐free survival and shape of the ablation volume under clinical conditions. Methods All participants provided written, informed consent, and study protocols were approved by the institutional ethics committee. Twenty‐seven patients with 27 nodules were treated by no‐touch ablation using the new simulator system. Another 21 patients with 21 nodules treated without the simulator system were enrolled as controls. Tumor progression and shape of ablation volume were assessed. Predictors of tumor progression were assessed by Cox proportional hazard model. Results No significant differences in clinical characteristics were seen between groups. Mean sphericity was 0.48 ± 0.07 with 3‐D sim‐Navigator and 0.37 ± 0.07 without 3‐D sim‐Navigator (P < 0.001). Median surface‐to‐volume ratio and compactness were also significantly closer to those of a sphere with 3‐D sim‐Navigator (P = 0.017, P < 0.001). Relapse‐free survival rates at 1 and 1.5 years were 94.1% and 82.4%, respectively, with 3‐D sim‐Navigator, compared with 83.2% and 55.5% without (P = 0.056). The only independent factor predicting relapse‐free survival was use of 3‐D sim‐Navigator (hazard ratio, 0.12; 95%CI, 0.01–0.87; P = 0.035). Conclusions Ideal ablation area was acquired by this simulation and navigation system in clinics. This system improved local tumor progression by facilitating appropriate insertion of multiple electrodes.Keywords
Funding Information
- Japan Society for the Promotion of Science (15K09960, 15K09006)
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