Cerebral glucose metabolism in preclinical and prodromal Alzheimer’s disease
- 1 November 2010
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Neurotherapeutics
- Vol. 10 (11), 1667-1673
- https://doi.org/10.1586/ern.10.136
Abstract
Assessment of regional cerebral glucose metabolism by (18)F-2-fluoro-2-deoxy-D-glucose (FDG)-PET at resting state is a standard functional technique to assess cerebral function. Group studies identified significant regional metabolic impairment in asymptomatic individuals at increased risk for dementia. Substantial impairment of FDG uptake in temporoparietal association cortices emerges as a reliable predictor of rapid progression to dementia in mild cognitive impairment patients and could, therefore, serve as a biomarker for the diagnosis of prodromal Alzheimer's disease. Frontal and temporoparietal metabolic impairment is closely related to progression of disease in longitudinal studies, and multicenter studies suggest its utility as an outcome parameter to increase the efficiency of therapeutic trials.Keywords
This publication has 63 references indexed in Scilit:
- Quantitative and Functional Magnetic Resonance Imaging TechniquesPublished by Informa UK Limited ,2016
- Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)NeuroImage, 2009
- Applications of Neuroimaging to Disease-Modification Trials in Alzheimer’s DiseaseBehavioural Neurology, 2009
- Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteriaThe Lancet Neurology, 2007
- Mild Cognitive Impairment as a Clinical Entity and Treatment TargetArchives of Neurology, 2005
- Apolipoprotein E ϵ4 Count Affects Age at Onset of Alzheimer Disease,but Not Lifetime SusceptibilityArchives of General Psychiatry, 2004
- PET studies in dementiaAnnals of Nuclear Medicine, 2003
- Discrimination between Alzheimer Dementia and Controls by Automated Analysis of Multicenter FDG PETNeuroImage, 2002
- Impairment of Neocortical Metabolism Predicts Progression in Alzheimer’s DiseaseDementia and Geriatric Cognitive Disorders, 1999
- Rapid Assessment of Regional Cerebral Metabolic Abnormalities in Single Subjects with Quantitative and Nonquantitative [18F]FDG PET: A Clinical Validation of Statistical Parametric MappingNeuroImage, 1999