Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder
Open Access
- 1 January 2016
- journal article
- Published by Korean Neuropsychiatric Association in Psychiatry Investigation
- Vol. 13 (3), 321-326
- https://doi.org/10.4306/pi.2016.13.3.321
Abstract
Anxious depression has a distinct neurobiology, clinical course and treatment response from non-anxious depression. Role of inflammation in anxious depression has not been examined. As an exploratory study to characterize the role of inflammation on a development of anxious depression, we aimed to determine the relationship between white blood cell (WBC) subset counts and anxiety in individuals with major depressive disorder (MDD). A total of 709 patients who were newly diagnosed with MDD were recruited. Anxiety levels of participants were evaluated using the Anxiety/ Somatization subitem of the Hamilton Depression Rating Scale. The association between WBC subset fraction and anxiety was evaluated. Basophil and eosinophil sub-fractions showed significant negative correlations with HAM-D anxiety/somatization factor scores (basophils: r=-0.092, p=0.014 and eosinophils: r=-0.075, p=0.046). When an anxiety score (a sum of somatic and psychic anxiety) was entered as a dependent variable, only basophils showed significant negative association with the anxiety scores after adjusting for all other WBC subset counts and demographic factors (t=-2.57, p=0.010). This study showed that anxious depression had a decreased basophil subfraction, which might be associated with involvement of inflammation in development of anxious depression.Keywords
This publication has 32 references indexed in Scilit:
- Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral StatesPLOS ONE, 2013
- Aspirin: a review of its neurobiological properties and therapeutic potential for mental illnessBMC Medicine, 2013
- Severe and anxious depression: Combining definitions of clinical sub-types to identify patients differentially responsive to selective serotonin reuptake inhibitorsEuropean Neuropsychopharmacology, 2012
- The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-AnalysisNeuropsychopharmacology, 2011
- Association of high-sensitivity C-reactive protein with de novo major depressionThe British Journal of Psychiatry, 2010
- Seeds of Arabidopsis plants expressing dominant-negative AtSKD1 under control of the GL2 promoter show atransparent testaphenotype and a mucilage defectPlant Signaling & Behavior, 2010
- Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major DepressionBiological Psychiatry, 2009
- Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*DPsychological Medicine, 2004
- Does comorbid subthreshold anxiety affect clinical presentation and treatment response in depression? A preliminary 12-month naturalistic studyInternational Journal of Neuropsychopharmacology, 1999
- Chronic stress and sympathetic-adrenal medullary responsivenessSocial Science & Medicine (1982), 1988