The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016
Open Access
- 2 November 2017
- journal article
- Published by European Centre for Disease Control and Prevention (ECDC) in Eurosurveillance
- Vol. 22 (44), 17-00102
- https://doi.org/10.2807/1560-7917.es.2017.22.44.17-00102
Abstract
Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14–48 years and 573 (19%) had laboratory-confirmed ZIKV infection. Rash, arthralgia, myalgia and conjunctival hyperaemia were more frequently observed in ZIKV-positive women; 23% of them (95% confidence interval (CI): 20–27) had at least one symptom compatible with ZIKV infection. Women 30 years and older were significantly more likely to have symptoms than younger women (28% vs 20%). The proportion of symptomatic infections varied from 17% in the remote interior to 35% in the urbanised population near the coast (adjusted risk ratio: 1.6; 95% CI: 1.4–1.9.). These estimates put findings on cohorts of symptomatic ZIKV-positive pregnant women into the wider context of an epidemic with mainly asymptomatic infections. The proportion of symptomatic ZIKV infections appears to vary substantially between populations.Keywords
This publication has 29 references indexed in Scilit:
- Zika Virus Disease in Colombia — Preliminary ReportThe New England Journal of Medicine, 2020
- Zika emergence in the French Territories of America and description of first confirmed cases of Zika virus infection on Martinique, November 2015 to February 2016Eurosurveillance, 2016
- Evidence of Sexual Transmission of Zika VirusThe New England Journal of Medicine, 2016
- Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case studyThe Lancet Infectious Diseases, 2016
- The Emerging Zika Virus Epidemic in the AmericasJAMA, 2016
- Zika virus in the Americas: Early epidemiological and genetic findingsScience, 2016
- Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission — Continental United States, 2016Morbidity and Mortality Weekly Report (MMWR), 2016
- Zika Virus in the Americas — Yet Another Arbovirus ThreatThe New England Journal of Medicine, 2016
- Zika virus genome from the AmericasThe Lancet, 2016
- Probable Non–Vector-borne Transmission of Zika Virus, Colorado, USAEmerging Infectious Diseases, 2011