Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex
Open Access
- 31 May 2011
- journal article
- review article
- Published by Hindawi Limited in Neural Plasticity
- Vol. 2011, 1-14
- https://doi.org/10.1155/2011/614329
Abstract
Cortical injuries are often reported to induce a suppression of the intracortical GABAergic inhibition in the surviving, neighbouring neuronal networks. Since GABAergic transmission provides the main source of inhibition in the mammalian brain, this condition may lead to hyperexcitability and epileptiform activity of cortical networks. However, inhibition plays also a crucial role in limiting the plastic properties of neuronal circuits, and as a consequence, interventions aiming to reestablish a normal level of inhibition might constrain the plastic capacity of the cortical tissue. A promising strategy to minimize the deleterious consequences of a modified inhibitory transmission without preventing the potential beneficial effects on cortical plasticity may be to unravel distinct GABAergic signaling pathways separately mediating these positive and negative events. Here, gathering data from several recent studies, we provide new insights to better face with this “double coin” condition in the attempt to optimize the functional recovery of patients.Keywords
This publication has 126 references indexed in Scilit:
- Metaplasticity of horizontal connections in the vicinity of focal laser lesions in rat visual cortexJournal Of Physiology-London, 2010
- Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after strokeNature, 2010
- Epilepsy following cortical injury: Cellular and molecular mechanisms as targets for potential prophylaxisEpilepsia, 2009
- Neuroprotection for ischemic stroke: Past, present and futureNeuropharmacology, 2008
- Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexNature Reviews Neuroscience, 2008
- Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortexNature Neuroscience, 2007
- Lighting the chandelier: new vistas for axo-axonic cellsTrends in Neurosciences, 2005
- Variations on an inhibitory theme: phasic and tonic activation of GABAA receptorsNature Reviews Neuroscience, 2005
- Synaptic Modification by Correlated Activity: Hebb's Postulate RevisitedAnnual Review of Neuroscience, 2001
- Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex.Proceedings of the National Academy of Sciences of the United States of America, 1989