Molecular biology of histidine decarboxylase and prostaglandin receptors
Open Access
- 1 January 2010
- journal article
- review article
- Published by Japan Academy in Proceedings of the Japan Academy, Series B
- Vol. 86 (8), 848-866
- https://doi.org/10.2183/pjab.86.848
Abstract
Histamine and prostaglandins (PGs) play a variety of physiological roles as autacoids, which function in the vicinity of their sources and maintain local homeostasis in the body. They stimulate target cells by acting on their specific receptors, which are coupled to trimeric G proteins. For the precise understanding of the physiological roles of histamine and PGs, it is necessary to clarify the molecular mechanisms involved in their synthesis as well as their receptor-mediated responses. We cloned the cDNAs for mouse L-histidine decarboxylase (HDC) and 6 mouse prostanoid receptors (4 PGE2 receptors, PGF receptor, and PGI receptor). We then characterized the expression patterns and functions of these genes. Furthermore, we established gene-targeted mouse strains for HDC and PG receptors to explore the novel pathophysiological roles of histamine and PGs. We have here summarized our research, which should contribute to progress in the molecular biology of HDC and PG receptors. (Communicated by Osamu HAYAISHI, M.J.A.)Keywords
This publication has 109 references indexed in Scilit:
- Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent mannerBiochemical and Biophysical Research Communications, 2009
- Prostanoid receptor antagonists: development strategies and therapeutic applicationsBritish Journal of Pharmacology, 2009
- The prostaglandin receptor EP2 activates multiple signaling pathways and -arrestin1 complex formation during mouse skin papilloma developmentCarcinogenesis: Integrative Cancer Research, 2009
- RhoA/Rho Kinase Signaling in the Cumulus Mediates Extracellular Matrix AssemblyEndocrinology, 2009
- Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilizationProceedings of the National Academy of Sciences of the United States of America, 2008
- Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of diseaseThe Journal of Experimental Medicine, 2008
- Augmentation of Receptor-Mediated Adenylyl Cyclase Activity by Gi-Coupled Prostaglandin Receptor Subtype EP3 in a Gβγ Subunit-Independent MannerBiochemical and Biophysical Research Communications, 2002
- Characterization of the LPS-Stimulated Expression of EP2 and EP4 Prostaglandin E Receptors in Mouse Macrophage-like Cell Line, J774.1Biochemical and Biophysical Research Communications, 1998
- Patent Ductus Arteriosus and Neonatal Death in Prostaglandin Receptor EP4-Deficient MiceBiochemical and Biophysical Research Communications, 1998
- Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient MiceCell, 1997