LRRK2
- 13 September 2005
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 65 (5), 664-665
- https://doi.org/10.1212/01.wnl.0000179342.58181.c9
Abstract
LRRK2 seems likely to contribute to more typical, idiopathic PD. Mutations have been reported in patients of all ages. However, LRRK2 has posed major challenges for researchers. The most formidable is the size of the gene. LRRK2 includes 51 exons. As a result, thorough screening of this gene to identify novel mutations is costly and time-consuming. Three articles in this issue of Neurology have taken different approaches to this difficult problem. Two …Keywords
This publication has 10 references indexed in Scilit:
- A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutationsNeurology, 2005
- LRRK2 mutations in Parkinson diseaseNeurology, 2005
- LRRK2 gene in Parkinson diseaseNeurology, 2005
- Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutationAnnals of Neurology, 2005
- LRRK2 mutations and ParkinsonismThe Lancet, 2005
- A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's diseaseThe Lancet, 2005
- Genetics of Parkinson diseaseNeuroRX, 2004
- Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson diseaseNeurology, 2003
- Complex relationship between Parkin mutations and Parkinson diseaseAmerican Journal of Medical Genetics, 2002
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismNature, 1998