Kinetic Studies of the Mechanism of Thrombocytopenia in Patients with Human Immunodeficiency Virus Infection
Open Access
- 17 December 1992
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 327 (25), 1779-1784
- https://doi.org/10.1056/nejm199212173272503
Abstract
Isolated thrombocytopenia accompanied by increased amounts of platelet-associated antibody is a common manifestation of human immunodeficiency virus (HIV) infection, and the thrombocytopenia often improves with zidovudine. It is not clear whether the mechanism of HIV-related thrombocytopenia primarily involves autoimmune destruction of platelets or reduced platelet production by megakaryocytes.Keywords
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