Apoptosis and loss of virus-specific CD8+ T-cell memory
- 30 June 2004
- journal article
- review article
- Published by Elsevier BV in Current Opinion in Immunology
- Vol. 16 (3), 271-276
- https://doi.org/10.1016/j.coi.2004.03.020
Abstract
CD8+ T-cell memory to viruses is stable in the absence but volatile in the presence of other infections. Apoptotic events that occur early in acute infections delete pre-existing memory T cells, leaving the host with reduced memory (except for cross-reactive responses) to previously encountered viruses. Apoptotic events also silence the acute immune response, leaving the host with a residual population of memory T cells. Persistent infections can induce apoptotic deletions of memory T cells that are specific to the persisting virus and to previously encountered pathogens.Keywords
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