Cytokine levels in patients with chikungunya virus infection
Open Access
- 19 June 2013
- journal article
- Published by Medknow in Asian Pacific Journal of Tropical Medicine
- Vol. 6 (8), 631-634
- https://doi.org/10.1016/s1995-7645(13)60108-x
Abstract
Objective: To investigate cytokine profile in patients with chikungunya virus (CHIKV) infection. Methods: Twenty eight pairs of serum samples collected from CHIKV infected patients during the outbreak of chikungunya fever in South Thailand in 2008 were obtained. A multiple cytokine assay for detection of 17 cytokines was performed. Results: In the acute stage of CHIKV infection, the patients had significantly higher levels of interleukin-6, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and tumor necrosis factor alpha than the control (PP=0.023, P=0.015, PP=0.024, respectively). When the disease developed to the recovery stage, the patients had significantly lower levels of interleukin-6, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and macrophage inflammatory protein beta than in the acute stage (P<0.001). Conclusions: This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection and could be used as disease biomarkers or drug targets.Keywords
This publication has 14 references indexed in Scilit:
- Expression profile of immune response genes during acute myopathy induced by chikungunya virus in a mouse modelMicrobes and Infection, 2012
- A Cytokine-Centric View of the Pathogenesis and Treatment of Autoimmune ArthritisJournal of Interferon & Cytokine Research, 2011
- Rapid point–of–care diagnosis of chikungunya virus infectionAsian Pacific Journal of Tropical Disease, 2011
- Inflammatory Cytokine Expression Is Associated with Chikungunya Virus Resolution and Symptom SeverityPLoS Neglected Tropical Diseases, 2011
- Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating FactorThe Journal of Infectious Diseases, 2011
- The Acute Phase of Chikungunya Virus Infection in Humans Is Associated With Strong Innate Immunity and T CD8 Cell ActivationThe Journal of Infectious Diseases, 2010
- Serum IL-18 and IL-18BP Levels in Patients with Chikungunya Virus InfectionViral Immunology, 2010
- Guillain-Barré Syndrome after Chikungunya InfectionEmerging Infectious Diseases, 2009
- IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya SeverityPLOS ONE, 2009
- An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–1953: An additional note on Chikungunya virus isolations and serum antibodiesTransactions of the Royal Society of Tropical Medicine and Hygiene, 1957