Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
- 15 April 2007
- journal article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 39 (5), 593-595
- https://doi.org/10.1038/ng2025
Abstract
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALLThis publication has 13 references indexed in Scilit:
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